Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is ...

About a third to two-thirds down the shaft of a chromosome is a constricted site called the centromere. When a chromosome replicates, the old and new pair (called chromatids) are held together at this ...

Centromeres are curious structures. These specially organized chromosomal regions are best known for their unique and critical role in cell division, in which they are well understood to serve as the ...

A research team at The University of Osaka has found a novel pathway for depositing CENP-A into vertebrate centromeres, which ...

Just like you might use a belt to keep your clothes in place, the centromere holds a pair of chromatids together and attaches it to the mitotic spindle during cell division to ensure that each ...

Despite the immense amount of genetic material present in each cell, around 3 billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities. The ...

The centromere of chromosomes plays a crucial role in cell division. Using the model plant Arabidopsis thaliana, an international team of researchers has investigated how two crucial proteins -- KNL2 ...

Super-resolution microscopy image of a mitotic chromosome (white) with the centromeres of each sister chromatid depicted in orange. Each centromere consists of two distinct chromatin subdomains ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

Pairing of homologous chromosomes in meiosis is critical for their segregation to daughter cells. In most eukaryotes, clustering of telomeres precedes and facilitates chromosome pairing. In several ...