Biomea Fusion is a clinical-stage company focused on developing covalent small molecules for diabetes and genetically-defined cancers. The company highlighted positive phase 2 trial results for its ...

Although small molecules can be excellent at finding and binding deep pockets on proteins of interest, many therapeutic targets with smooth surfaces remain hard to get a good handle on. Partly as a ...

Terremoto Biosciences has launched with $75 million in series A financing to discover small-molecule drugs using its lysine-targeted covalency technology. Terremoto says most drugs that bind to ...

EMERYVILLE, Calif., Oct. 27, 2022 /PRNewswire/ -- Totus Medicines, a drug discovery company with the mission to make any protein druggable through its breakthrough chemical biology platform, announced ...

Molly Gibson, PhD, has focused her attention on building companies at the intersection of AI and life sciences for the past decade, having co-founded both Generate: Biomedicines and Lila Sciences.

In a recent study posted to the bioRxiv* preprint server, researchers performed an extensive library docking for new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) ...

Matchpoint Therapeutics has been served $70 million in series A funds to fund its covalent molecule ambitions, prioritizing platform development and early discovery work. After raising $30 million in ...

Graphene oxide is composed of oxygenated functional groups, the most prevalent of which are carboxyl, carbonyl, epoxy, and hydroxyl. These functional groups present on graphe are polar, making it very ...

Although covalent drugs have been used for more than a century, the emergence of new tools has helped spur recent advances in the field. Indeed, covalent medicine experienced a resurgence roughly 15 ...

Researchers have now developed an electrically driven system for carbon capture using covalent organic frameworks (COFs) ( Chem 2026, DOI: 10.1016/j.chempr.2025.102910). Using simple open-air ...

In nature, molecules often show a strong preference for partnering with other molecules that share the same chirality or handedness. A behavior that is quite evident in the phenomenon known as ...