A new analysis of the ISCHEMIA trial reveals its results are highly contingent on how myocardial infarction is defined, with investigators reporting a significant treatment difference between the ...

Ischemic colitis reduces blood flow to the colon or large intestine. Mesenteric ischemia is a reduction in blood flow to the small intestine due to the narrowing of the arteries. Both conditions are ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

A key lesson one can learn from experience in designing clinical trials is that the devil is often in the details. Trial design is equally as important as—if not more important than—trial execution.

Myocardial ischemia is a drop in blood flow to the heart. Myocardial infarction, or heart attack, occurs when death or damage occurs in the muscle tissue of the heart due to low blood supply. The ...