Every stem cell faces a decision to become a mature epidermal cell or switch to becoming a hair follicle cell. This so-called fate switch is governed by the transcription factor SOX9. If the ...

Hair follicle stem cells (green) mobilize and expand (white) to help repair the skin’s barrier by differentiating into epidermal lineages (red). When a child falls off her bike and scrapes her knee, ...

Humans aren't capable of regenerating lost limbs, but our bodies can heal from many wounds. Whenever we scratch or cut our skin, for example, skin stem cells move in to regrow the epidermis and repair ...

Fluctuation in signal transduction pathways is frequently observed during mammalian development. However, its role in regulating stem cells has not been explored. Here we tracked spatiotemporal ERK ...

In skin, some aberrant adult epidermal stem cells turn on SOX9, kickstarting a process that ultimately activates cancer genes. Early on, every stem cell faces a fateful choice. During skin development ...

Your skin is in a constant state of reinvention. Every month, your body sheds and regenerates its entire outer layer—a complete turnover powered by tiny, tireless stem cells. These same cells spring ...

Blood sampling is painful and invasive, plus it only tells you what's going on in the patient's body right when the sample is ...

Learn how engineered skin turns internal biological signals into visible light, offering a new way to monitor inflammation ...